Frequently Asked Questions

FAQ: Frequently Asked Questions About
AFREZZA® Inhaled Insulin

You have questions about AFREZZA; we have answers. Below are answers to some frequently asked questions (FAQ). However, only your healthcare professional can help you decide if AFREZZA is right for you. Please see Important Safety Information and Full Prescribing Information, including Boxed WARNING.

What is AFREZZA®?

AFREZZA is a man-made, mealtime insulin that is breathed-in through your lungs (inhaled) and is used to control high blood sugar in adults with diabetes mellitus.

How can AFREZZA® help me manage my diabetes?

AFREZZA has been proven to help control blood sugar levels. If your diabetes medications are not giving you the control you need, adding AFREZZA can help control the blood sugar rise that occurs after you eat.

Will AFREZZA® replace my current long-acting insulin?

If you already take a long-acting insulin, your healthcare professional will tell you to continue to do so. You can add AFREZZA to treat the mealtime spike of your blood sugar.

Can I take AFREZZA® with diabetes pills?

AFREZZA can be taken with oral diabetes medicines. Be sure to tell your healthcare professional about all other medicines and supplements you are taking because they can affect the way your insulin works.

Could AFREZZA® be right for me?

AFREZZA is not for people with lung disease or who smoke or have recently quit smoking. Before prescribing, your healthcare professional will conduct a medical exam and breathing test (spirometry). Do not use AFREZZA if you are allergic to regular human insulin or any of the ingredients in AFREZZA.

 

It is not known if AFREZZA is safe and effective in children under 18 years of age.

What is a spirometry test?

Spirometry is used to diagnose asthma, chronic obstructive pulmonary disease (COPD), and other conditions that affect breathing. If the test shows that you have problems with your lungs, you should not use AFREZZA.

 

Before prescribing AFREZZA, your healthcare professional will give you a medical exam and breathing test (spirometry).This test is used to see how well your lungs work. It measures how much air you breathe in and out and how long it takes for you to exhale completely.

 

Your healthcare provider should check how your lungs are working before you start using AFREZZA, 6 months after you start using it and yearly after that.

When should I inhale AFREZZA®?

AFREZZA should be inhaled at the beginning of a meal. Take AFREZZA exactly as your healthcare provider tells you to. Your healthcare provider should tell you how much AFREZZA to use and when to use it. Read the detailed Instructions for Use that comes with your AFREZZA.

Is it normal to see some powder left over in my inhaler after I’ve inhaled my AFREZZA® dose?

A small amount of powder residue in the mouthpiece or cartridge is normal. This does not affect your dose.

Can I wash my AFREZZA® inhaler?

Never wash the inhaler. You can wipe the mouthpiece with a clean, dry cloth to remove moisture or lipstick.

Should I test my blood sugar while taking AFREZZA®?

Checking your blood sugar levels around mealtime, and keeping track of the levels, helps you and your healthcare professional monitor your progress over time and determine how well your treatment plan is working. Talk to your healthcare provider about what your blood sugar should be and when you should check your blood sugar levels.

 

Download our blood sugar log and use it to track your levels.

What should I do if I develop a cough while taking AFREZZA®?

In studies, cough was reported in about 27% of patients using AFREZZA; 2.8% of patients gave cough as a reason for stopping AFREZZA. Talk to your healthcare professional if you develop a persistent or recurring cough or breathing difficulties while taking AFREZZA.

How can I get additional support for AFREZZA®?

For reimbursement support, contact MannKind CaresSM at 1-844-3AFREZZA. More information can be found at AFREZZA Support.

 

For any questions regarding medical issues, contact Mannkind Corporate at 1-877-323-8505.

Is AFREZZA® covered by insurance?

AFREZZA may be covered by your insurance plan. If your doctor recommends AFREZZA for you, call your insurance provider to check whether AFREZZA is covered. You may also be able to save on your prescriptions with an AFREZZA Savings Card. Restrictions may apply.*

Get Savings Card

What is the most important information I should know about AFREZZA? AFREZZA can cause serious side effects including: Sudden lung problems (bronchospasms). Do not use AFREZZA if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting AFREZZA, your healthcare provider will perform a detailed medical history, physical examination, and will give you a breathing test (called spirometry) to check how your lungs are working.

AFREZZA is a man-made rapid-acting inhaled insulin breathed in through your lungs and is used to control high blood sugar in adults with diabetes. AFREZZA is available by prescription only.

  • AFREZZA is not for use in place of long-acting insulin. AFREZZA must be used with long-acting insulin in people who have type 1 diabetes.
  • AFREZZA is not for use to treat diabetic ketoacidosis.
  • It is not known if AFREZZA is safe and effective for use in people who smoke. AFREZZA is not for use in people who smoke or have recently stopped smoking (less than 6 months).
  • It is not known if AFREZZA is safe and effective in children under 18 years of age.
What is the most important information I should know about AFREZZA?

AFREZZA can cause serious side effects including:

  • Sudden lung problems (bronchospasms). Do not use AFREZZA if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting AFREZZA, your healthcare provider will perform a detailed medical history, physical examination, and will give you a breathing test (called spirometry) to check how your lungs are working.

Who should not use AFREZZA?

Do not use AFREZZA:

  • During episodes of low blood sugar (hypoglycemia).
  • If you have chronic lung problems such as asthma or COPD.
  • If you are allergic to regular human insulin or any of the ingredients of AFREZZA as this may cause a significant and severe allergic reaction.

What should I tell my healthcare provider before using AFREZZA?

Before using AFREZZA, tell your healthcare provider about all your medical conditions, including if you:

  • Have lung problems such as asthma or COPD.
  • Have or have had lung cancer.
  • Are using any inhaled medications.
  • Smoke or have recently stopped smoking.
  • Have kidney or liver problems.
  • Are pregnant, planning to become pregnant, or are breastfeeding. AFREZZA may harm your unborn or breastfeeding baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements.

Before you start using AFREZZA, talk to your healthcare provider about low blood sugar and how to manage it.

How should I use AFREZZA?

  • Read the detailed Instructions for Use that comes with your AFREZZA.
  • Take AFREZZA exactly as your healthcare provider tells you to, including how much AFREZZA to use and when to use it.
  • Know the strength of AFREZZA you use. Do not change the amount of AFREZZA you use unless your healthcare provider tells you to.
  • Take AFREZZA at the beginning of your meal.
  • Check your blood sugar levels. Ask your healthcare provider what your blood sugar level should be and when you should check your blood sugar levels.
  • Keep AFREZZA and all medicines out of reach of children.

Your dose of AFREZZA may need to change because of:

  • Change in level of physical activity or exercise, weight gain or loss, increased stress, illness, change in diet, or because of other medicines you take.

What should I avoid while using AFREZZA?

While using AFREZZA do not:

  • Drive or operate heavy machinery, until you know how AFREZZA affects you.
  • Drink alcohol or use over-the-counter medicines that contain alcohol.
  • Smoke.

What are the possible side effects of AFREZZA?

AFREZZA may cause serious side effects that can lead to death including:

  • Low blood sugar (hypoglycemia). Signs and symptoms of low blood sugar include:
    • Dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood change, hunger.
  • Decreased lung function. Your healthcare provider should check how your lungs are working before you start AFREZZA, 6 months after you start using it, and yearly after that.
  • Lung cancer. In studies of AFREZZA in people with diabetes, lung cancer occurred in a few more people who were taking AFREZZA than in people who were taking other diabetes medications. There were too few cases to know if lung cancer was related to AFREZZA. If you have lung cancer, you and your healthcare provider should decide if you should use AFREZZA.
  • Diabetic ketoacidosis. Talk to your healthcare provider if you have an illness. Your AFREZZA dose or how often you check your blood sugar may need to be changed.
  • Severe allergic reaction (whole body reaction). Get medical help right away if you have any of these signs or symptoms of a severe allergic reaction:
    • A rash over your whole body, trouble breathing, a fast heartbeat, or sweating.
  • Low potassium in your blood (hypokalemia).
  • Heart failure. Taking certain diabetes pills called thiazolidinediones (TZDs) with AFREZZA may cause heart failure in some people. This can happen even if you never had heart failure or heart problems before. If you already have heart failure it may get worse while you take TZDs with AFREZZA. Your healthcare provider should monitor you closely while you are taking TZDs with AFREZZA. Tell your healthcare provider if you have any new or worse symptoms of heart failure including:
    • Shortness of breath, swelling of your ankles or feet, sudden weight gain.

Treatment with TZDs and AFREZZA may need to be changed or stopped by your healthcare provider if you have new or worse heart failure.

Get emergency medical help if you have trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.

The most common side effects of AFREZZA are low blood sugar (hypoglycemia), cough, sore throat, headache, diarrhea, tiredness and nausea.

These are not all the possible side effects of AFREZZA. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of all prescription drugs to the FDA.

Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please click here for full Prescribing Information, including Boxed WARNING, Medication Guide, and Instructions for Use for AFREZZA.

*Offer is not valid for patients if their prescriptions are paid in part or in full by any state or federally funded programs, including, but not limited to, Medicare or Medicaid, Medigap, VA, DOD or TRICARE. Offer is not valid, where prohibited by law. MannKind Corporation reserves the right to rescind, revoke, or amend this offer without notice. Maximum benefit is $150 per prescription depending on your out-of-pocket costs for the duration of the program. Eligibility criteria: Only patients who reside in the United States, Puerto Rico, Guam or the U.S. Virgin Islands can participate in this program. If you have any questions about this program, please call 855-262-5296, or if you have questions about AFREZZA, talk to your healthcare professional.