Afrezza is a rapid acting insulin that may help you keep your blood sugar in control after meals. Afrezza is available by prescription only and is for adults living with type 1 or type 2 diabetes.
If you are not seeing the blood sugar results you expect, please talk to your healthcare provider. You may need to adjust your dose.
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When using Afrezza, like any insulin medication, it is important to work with your healthcare provider to find best dose and schedule for you. If you are not getting the sugar control you expect, please speak to your healthcare provider about adjusting your dose.
If you have never used mealtime insulin before, your healthcare provider will start you at a dose of Afrezza at each meal to see if this works for you.
If you have been taking injected mealtime insulin, you probably have settled into a routine and use a fixed number of injected insulin units per meal or snack.
There is not a straight conversion from your injected dose of insulin to your inhaled dose of Afrezza. You and your healthcare provider can determine the appropriate dose of Afrezza that is right for you.
Ask your healthcare provider what your blood sugar level should be, and when you should check your blood sugar levels. It's important to test your blood sugar levels frequently- especially when starting Afrezza for the first time. Monitoring your blood sugar levels can help you and your healthcare provider determine the right dose of Afrezza your body needs for your meals. You can track your blood sugar levels using our blood sugar log template. Share your results with your healthcare provider who can help determine how well your treatment program is working for you.DOWNLOAD BLOOD SUGAR LOG
For Afrezza doses exceeding 12 units, inhalations from multiple cartridges are necessary. To achieve the required total mealtime dose, you should use a combination of 4, 8 and 12 Afrezza unit cartridges as pictured above.
Afrezza insulin units are different than injected insulin units because Afrezza is inhaled and in powder form, while other mealtime insulins are in a liquid form and injected. Your healthcare provider will start you on a dose considered best for you.
Life is constantly changing and Afrezza can be adapted to your activities and schedule. Afrezza dosing should be individualized. This table can help with initial mealtime dose when converting. As you start your new therapy, get to know how Afrezza works for you and let your healthcare provider know your progress.
If your prescribed Afrezza dose is more than 12 units you will need to use more than 1 cartridge to get your right dose. Multiple inhalations will be necessary.
Repeat steps 2 through 4 for each Afrezza cartridge you need for your dose.
Each package of Afrezza comes with 2 inhalers. Use 1 inhaler at a time and replace it after 15 days.
Once you have taken your full dose, make sure the purple mouthpiece cover has been replaced and the inhaler is closed.
Tip: Keep track of 15 days from when you start using the inhaler with a calendar, or use the chart on the back of the inhaler box.
Afrezza insulin comes in 4, 8 and 12 unit color-coded cartridges. Cartridges containing the fast-acting insulin are sealed in foil packages containing 2 blister cards with 15 cartridges each. Cards are perforated so you can easily remove 3 cartridges at a time.
It's important not to mix new and used cartridges. Keep new cartridges in the foil pack until right before use. Discard used cartridges right away.
TIP: New cartridges have the cup positioned forward near the point. Used cartridges will have the cup positioned in the center.
|Opened package||May be used for up to 15 days|
|Not in use: Refrigerated storage||Refrigerated (36˚-46˚)|
|Sealed (Unopened)*||May be used until the expiration date|
|Blister card and strips||Sealed (Unopened)*||Must be used within 1 month|
|In use: Room temperature storage||Room temperature|
|Blister cards and strips||Sealed (Unopened)||Must be used within 10 days|
|Strips||Opened||Must be used within 3 days|
|Do not put a blister card or strip back into the refrigerator after being stored at room temperature.|
|Before use, cartridge and inhaler should be at room temperature for 10 minutes.|
* If a foil package, blister card, or strip is not refrigerated, the content must be used within 10 days.
MannKind is committed to helping people gain access to Afrezza.
MannKind Cares supports people with diabetes and caregivers who have questions about Afrezza. We understand the challenges people may face with the healthcare system and are here to help. MannKind Cares provides support services to help answer your questions related to insurance coverage, prescription cost, and product use.
If your doctor recommends Afrezza for you, ask your physician about enrolling you in MannKind Cares. We will work with your insurance provider to check whether Afrezza is covered and provide support to get your prescription filled. Please contact us if you have questions.
1-844-323-7399, 8:30am-8:00pm ET
Monday through Friday
Afrezza can cause serious side effects, including: Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza, your healthcare provider will give you a breathing test to check how your lungs are working.
Afrezza can cause serious side effects, including: Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD).
Afrezza can cause serious side effects, including:
Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza, your healthcare provider will give you a breathing test to check how your lungs are working.
Do not use Afrezza if you:
Before using Afrezza, tell your healthcare provider about all your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements.
Before you start using Afrezza, talk to your healthcare provider about low blood sugar and how to manage it.
While using Afrezza do not:
Afrezza may cause serious side effects that can lead to death, including:
See “What is the most important information I should know about Afrezza?” at the top of this page.
Treatment with TZDs and Afrezza may need to be changed or stopped by your healthcare provider if you have new or worse heart failure.
Get emergency medical help if you have:
• Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.
The most common side effects of Afrezza include:
These are not all the possible side effects of Afrezza. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088).
Active ingredient: human insulin
Inactive ingredients: fumaryl diketopiperazine, polysorbate 80
General information about the safe and effective use of Afrezza.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Afrezza for a condition for which it was not prescribed. Do not give Afrezza to other people, even if they have the same symptoms that you have. It may harm them.
This Medication Guide summarizes the most important information about Afrezza. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about Afrezza that is written for health professionals.