Insulin you inhale at the beginning of your meal.

Afrezza is the only rapid acting insulin available that can be inhaled. Other mealtime insulin options are delivered through injection. Afrezza can potentially save you about 1,000 needle sticks per year. * 

If you're living with type 2 diabetes and working with your healthcare provider to improve your blood sugar control, he or she may prescribe a rapid acting insulin, also known as mealtime insulin. If you're living with type 1, rapid acting insulin is already part of your daily diabetes management. 

Ins

Afrezza can be used
by adults with type 1
or type 2 diabetes who:

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1

Need a rapid acting insulin

- or -

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2

Want to discontinue insulin injections with meals

- and -

Lungs

3

Don’t have lung problems (for example COPD, asthma, currently smoke or have stopped smoking <6 months)
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If diet, exercise, and your current diabetes medications are no longer giving you the blood sugar control you need, ask your healthcare provider about Afrezza. Afrezza may be able to help.

Why Inhale Your Insulin?

Inhale Afrezza at the beginning of your meal to bring down blood sugars caused by eating. After you inhale Afrezza, the insulin passes quickly through your lungs and into your bloodstream (in less than one minute).1 This allows insulin to get into your blood quickly and work on reducing blood sugars within about 12 minutes.2 This rapid action allows you to take Afrezza when you are ready to eat and not worry about timing your mealtime insulin in advance of your meals. 

Afrezza is designed to be in your body for approximately 1.5 - 4 hours,** depending on your dose.2 Once Afrezza leaves your system it doesn't continue to lower your blood sugar. This helps you time your insulin therapy to your insulin need. 

Afrezza Lungs Inhaler2

** For the 4 and 12 unit cartridges respectively.

Healthy Later

Stay Healthier Later

Research shows that the better you get your blood sugar in control, the lower your risk can be for long term complications such as eye, heart, kidney, and nerve damage.3

CONTROL HIGH BLOOD SUGAR FAST

By keeping your blood sugar levels in a healthy range through food choices, physical activity, and proper medications, you can avoid long-term diabetes complications.3

These complications can develop over many years and they all relate to how blood sugar (also called blood glucose) levels affect the blood vessels. Over time, high amounts of sugars in your blood can damage the body's blood vessels, both tiny (microvascular) and large (macrovascular).4

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Using inhaled insulin can mean 1 less injection per meal which is ~1,000 less needle sticks per year.*

Afrezza can be helpful for people who have problems with needles or their injection sites.

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REIMAGINE YOUR DAY

How will switching to inhaled insulin change your day?

  • Inhaled insulin provides an alternative to multiple mealtime injections.

Afrezza is not for use in place of long-acting insulin. Afrezza must be used with long-acting insulin in people who have type 1 diabetes.

  • For many people, meal schedules vary from day to day. Planning when to take your mealtime insulin is not always easy. Afrezza is taken when you are ready to eat.
  • Carrying Afrezza with you means one Afrezza inhaler and your Afrezza cartridges. They may fit right into your pocket.

How it works

Afrezza is insulin used at the beginning of a meal with an oral inhaler and one or more single-use cartridges. Afrezza cartridges comes in three doses: 4, 8 and 12-unit cartridges.

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Your healthcare provider will give you direction on how to take Afrezza and help you find the right dose per meal for you.

If you are switching from an injectable mealtime insulin to Afrezza, it is important to remember that Afrezza insulin units are different than injected insulin units. If you are not seeing the results you expect with Afrezza, contact your healthcare provider about changing your dose. 

If you require more than 12 units at a time, you can use multiple cartridges. 

HOW TO USE AFREZZA: A STEP-BY-STEP GUIDE

Please see full Prescribing Information, including boxed WARNING, Medication Guide, and Instructions for Use.

Step 1:Select the cartridge for your dose
Step 2:Load the cartridge
Step 3:Inhale Afrezza
Step 4:Remove cartridge and discard

Getting started

Afrezza is an FDA-approved medication for adults with type 1 or type 2 diabetes. Afrezza is available by prescription only.
Step 1:  Talk to your healthcare provider about getting a prescription for Afrezza
Step 2:  Sign up to receive support tips on how to get started successfully on Afrezza
Step 3:  Visit our page for Afrezza Users

Looking for a healthcare provider who has experience with Afrezza?

Find a Doctor    

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Notes
* Assumes 1 needle per meal, 3 meals per day for 365 days, rounded down. ** For the 4 and 12 unit cartridges respectively.

References
[1] Data on file
[2] Afrezza® Prescribing Information, Sept 2017.
[3] American Diabetes Association. Standards of Medical Care in Diabetes 2018. Diabetes Care 2018 Jan;  vol41 (Supplement 1): S1 -S2. doi: 10.2337/dc18-S004.
[4] Nathan DM, for the DCC/EDIC Research Group. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview. Diabetes Care. 2014;37(1):9-16. doi:10.2337/dc13-2112.

Important Safety Information for Afrezza (insulin human) Inhalation Powder

Afrezza can cause serious side effects, including: Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza, your healthcare provider will give you a breathing test to check how your lungs are working.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about Afrezza? Afrezza can cause serious side effects, including: Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD).

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about Afrezza?

Afrezza can cause serious side effects, including:

Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza, your healthcare provider will give you a breathing test to check how your lungs are working.

  • Afrezza is a man-made insulin that is breathed-in through your lungs (inhaled) and is used to control high blood sugar in adults with diabetes mellitus. 
  • Afrezza is not for use in place of long-acting insulin. Afrezza must be used with long-acting insulin in people who have type 1 diabetes mellitus. 
  • Afrezza is not for use to treat diabetic ketoacidosis. 
  • It is not known if Afrezza is safe and effective for use in people who smoke. Afrezza is not for use in people who smoke or have recently stopped smoking (less than 6 months). 
  • It is not known if Afrezza is safe and effective in children under 18 years of age.

Do not use Afrezza if you:

  • Have chronic lung problems such as asthma or COPD.
  • Are allergic to regular human insulin or any of the ingredients in Afrezza. See the end of this Medication Guide for a complete list of ingredients in Afrezza. 

Before using Afrezza, tell your healthcare provider about all your medical conditions, including if you:

  • Have lung problems such as asthma or COPD
  • Have or have had lung cancer
  • Are using any inhaled medications
  • Smoke or have recently stopped smoking
  • Have kidney or liver problems
  • Are pregnant, planning to become pregnant, or are breastfeeding. Afrezza may harm your unborn or breastfeeding baby.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements.

Before you start using Afrezza, talk to your healthcare provider about low blood sugar and how to manage it.

  • Read the detailed Instructions for Use that comes with your Afrezza.
  • Take Afrezza exactly as your healthcare provider tells you to. Your healthcare provider should tell you how much Afrezza to use and when to use it.
  • Know the strength of Afrezza you use. Do not change the amount of Afrezza you use unless your healthcare provider tells you to.
  • Take Afrezza at the beginning of your meal.
  • Check your blood sugar levels. Ask your healthcare provider what your blood sugar should be and when you should check your blood sugar levels.
  • Keep Afrezza and all medicines out of the reach of children.
  • Change in level of physical activity or exercise, weight gain or loss, increased stress, illness, change in diet, or because of other medicines you take. 

While using Afrezza do not:

  • Drive or operate heavy machinery, until you know how Afrezza affects you.
  • Drink alcohol or use over-the-counter medicines that contain alcohol.
  • Smoke.

Afrezza may cause serious side effects that can lead to death, including:

See “What is the most important information I should know about Afrezza?” at the top of this page.

  • Low blood sugar (hypoglycemia). Signs and symptoms that may indicate low blood sugar include:
    • Dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood change, hunger.
  • Decreased lung function. Your healthcare provider should check how your lungs are working before you start using Afrezza, 6 months after you start using it and yearly after that.
  • Lung cancer. In studies of Afrezza in people with diabetes, lung cancer occurred in a few more people who were taking Afrezza than in people who were taking other diabetes medications. There were too few cases to know if lung cancer was related to Afrezza. If you have lung cancer, you and your healthcare provider should decide if you should use Afrezza.
  • Diabetic ketoacidosis. Talk to your healthcare provider if you have an illness. Your Afrezza dose or how often you check your blood sugar may need to be changed.
  • Severe allergic reaction (whole body reaction). Get medical help right away if you have any of these signs or symptoms of a severe allergic reaction:
    • A rash over your whole body, trouble breathing, a fast heartbeat, or sweating.
  • Low potassium in your blood (hypokalemia).
  • Heart failure. Taking certain diabetes pills called thiazolidinediones or “TZDs” with Afrezza may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems before. If you already have heart failure it may get worse while you take TZDs with Afrezza. Your healthcare provider should monitor you closely while you are taking TZDs with Afrezza. Tell your healthcare provider if you have any new or worse symptoms of heart failure including:
    • Shortness of breath, swelling of your ankles or feet, sudden weight gain.

Treatment with TZDs and Afrezza may need to be changed or stopped by your healthcare provider if you have new or worse heart failure.

Get emergency medical help if you have:

• Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.

The most common side effects of Afrezza include:

  • Low blood sugar (hypoglycemia), cough, sore throat

These are not all the possible side effects of Afrezza. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088).

Active ingredient: human insulin

Inactive ingredients: fumaryl diketopiperazine, polysorbate 80

General information about the safe and effective use of Afrezza.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Afrezza for a condition for which it was not prescribed. Do not give Afrezza to other people, even if they have the same symptoms that you have. It may harm them.

This Medication Guide summarizes the most important information about Afrezza. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about Afrezza that is written for health professionals. For more information, go to www.afrezza.com or call MannKind Corp. 1-877-323-8505.